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diagnosis differential acidosis causes classification hematology lactic approach criticalcare dm2 false hba1c hgba1c laboratory reduction thromboticthrombocytopenicpurpura ttp typea typeb workup
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
Iron, B-12, or folate ... Reduction == Increase ... • Hemolytic anemia ... HgbA1c #Laboratory #Increase ... #Decrease #Diagnosis
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Differential Diagnosis Algorithm ... combination of: Decreased ... Hypochromic RBCs Decreased ... Deficiency • B12/Folate ... Differential #Diagnosis #Algorithm
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
Mild-to-moderate decrease ... result in severe anemia ... immune hemolytic anemia ... Mild-to-moderate elevation ... Serum lactate
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Elevation, Lactic ... Elevation Type ... Circulatory System • Increased ... muscle use • Decreased ... 30mmHg) - Severe anemia
Lactic Acidosis - Differential Diagnosis Framework Type A: Impaired O2 Delivery (DO2) • Decreased O2 Delivery: Hypotension
Delivery (DO2) • Decreased ... Shock, Severe Anemia ... Compartment Syndrome • Increased ... HIV, Malaria, Late ... Syndrome, where decreased
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