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diagnosis hepatology lfts liver transaminitis hepatitis alkaline biliary causes chemistry cholangitis cirrhosis comparison dehydrogenase disease enzymes hellp icp injury interpretation
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
for the liver ALP ... Transaminase, ALP ... / ULN ALT) / (ALP ... / ULN ALP) ... SinaiBmoreIMRes #Liver #FunctionTest
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Tests - Differential ... or AST > ALP): ... Wilsons, Pregnancy - AFLP ... Cholestatic Pattern (ALP ... kwburak #LFTs #Elevated
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
specificity to elevated ... > ALP: Typical ... disease • If ALP ... normal AST/ALT ... chemistry #diagnosis #differential
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Diagnosis Algorithm ... specificity to elevated ... > ALP: Typical ... GGT/5-NT: ↑ - ALP ... function may be abnormal
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
Alkaline Phosphatase (ALP ... ) Elevation - Differential ... ALP: - Enzymes ... - Increased ALP ... #Elevation #Differential
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... Diagnosis Algorithm ... • Pregnancy - AFLP ... disease US — Normal
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
Mild jaundice, Elevated ... to 10-20-fold elevation ... of Pregnancy (AFLP ... hepatitis #comparison #differential ... diagnosis #icp #HELLP #AFLP
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
tests algorithm ... magnitude of enzyme elevation ... ALP, alkaline phosphatase ... #Algorithm #Hepatology ... Liver #Enzymes #Differential
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
& AST normal or ... slightly elevated ... early on but elevated ... obstruction • ALP ... bile ducts Differential
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Elevated Lactate ... Dehydrogenase (LDH) - Differential ... upon damage • Normal ... Idiosyncratic LDH Elevation ... #differential #
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