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diagnosis hepatology causes hepatitis infectiousdiseases lactate lfts transaminitis acidosis aflp algorithm chemistry comparison dehydrogenase disease fever heat heatstroke hellp hyperferritinemia
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... (LFTs) Elevation ... specific for the liver ... #FunctionTest # ... LFTs #Elevation
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
Mild jaundice, Elevated ... to 10-20-fold elevation ... Syndrome (Hemolysis, Elevated ... to 10-20-fold elevation ... hepatitis #comparison #differential
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
specificity to elevated ... Bilirubin - +/- elevation ... or amyloid: • Elevation ... Enzyme Elevation ... chemistry #diagnosis #differential
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... specificity to elevated ... Bilirubin - +/- elevation ... Enzyme Elevation ... injury #hepatitis #differential
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Causes of Lactate Elevation ... Lactic Acidosis - Differential ... Causes of elevated ... #Differential # ... #typea #typeb #classification
Causes of Hyperferritinemia - Differential Diagnosis Ferritin > 1000 Ferritin is the storage form of iron. Increased hepcidin
Hyperferritinemia - Differential ... is made in the liver ... saturation to differentiate ... inflammatory causes of elevated ... extreme ferritin elevation
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Elevated Lactate ... Dehydrogenase (LDH) - Differential ... RBCs, muscle, liver ... Idiosyncratic LDH Elevation ... #differential #
Heat Illnesses and Heat Stroke - Differential Diagnosis Framework Heat Cramps: • Muscle pain or spasm -
Heat Stroke - Differential ... Muscles, Kidneys, Liver ... normal/mildly elevated ... acidosis - CPK elevation ... heat #illness #differential
Nontuberculous Mycobacteria (NTM) Infections Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
Growers (Runyon Classification ... Growers (Runyon Classification ... gastrointestinal symptoms (elevations ... of liver enzymes ... NTM #Infections #differential
Fever After International Travel Infectious Disease: • Endemic in either the destination or home region Viral Syndromes: Arboviral infections, a
thrombocytopenia, and elevated ... febrile illness, elevations ... including tests of liver ... Fever #Travel #Differential
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