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diagnosis hepatology causes liver algorithm lfts transaminitis hematology rheumatology autoimmune disease fever laboratory lactate travel workup acidosis aflp aih anatomic
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Function Test (LFTs) Elevation ... SinaiBmoreIMRes #Liver #FunctionTest ... #LFTs #Elevation
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Elevated Transaminases ... Transaminitis - Differential ... • Autoimmune hepatitis ... Transaminitis #Elevated ... #Differential #
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Elevated Lactate ... Dehydrogenase (LDH) - Differential ... It can remain elevated ... Idiosyncratic LDH Elevation ... #differential #
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
Mild jaundice, Elevated ... to 10-20-fold elevation ... to 10-20-fold elevation ... hepatology #obstetrics #hepatitis ... #comparison #differential
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Check Acute viral hepatitis ... Check Acute viral hepatitis ... specificity to elevated ... Bilirubin - +/- elevation ... chemistry #diagnosis #differential
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Elevated Liver Function ... Tests (LFTs) - Differential ... Chronic Viral Hepatitis ... • Acute Viral Hepatitis ... #Tests #LFTs #Differential
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Liver Injury - Differential ... specificity to elevated ... Bilirubin - +/- elevation ... of Liver Enzyme Elevation ... #differential #
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... • Alcoholic hepatitis ... #LiverEnzymes #Differential
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
Autoimmune Hepatitis ... IgG typically elevated ... (rare) - IgG Elevation ... Other Etiology of Hepatitis ... #Autoimmune #Hepatitis
Causes of ST Segment Elevation - Differential Diagnosis Framework STEMI: • Upsloping convex STE: "Pardee's sign" +
of ST Segment Elevation ... - Differential ... Diffuse ST-segment elevation ... segment becomes elevated ... #differential #
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