15 results
Causes of False Elevation and Reduction in HbA1c

== False Elevation ==
Decreased RBC turnover 
• Iron, B-12,
Causes of False ... == Decreased RBC ... • Asplenia Laboratory ... HbA1c #HgbA1c #Laboratory ... Diagnosis #DM2 #Differential
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory ... Mild-to-moderate decrease ... in most cases; ... Mild-to-moderate elevation ... WBC count and differential
Causes of Hyperferritinemia - Differential Diagnosis
Ferritin > 1000
Ferritin is the storage form of iron. Increased hepcidin
- Differential ... Decreased hepcidin ... saturation to differentiate ... of elevated ferritin ... extreme ferritin elevation
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis

The most common causes of hyperlactatemia are usually:
Acidosis - Differential ... Causes of elevated ... - assess other laboratory ... muscle use • Decreased ... #Differential #
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework

LDH is a cytoplasmic enzyme present in tissues throughout
Dehydrogenase (LDH) - Differential ... myocarditis, rheumatic fever ... Idiosyncratic LDH Elevation ... #differential # ... diagnosis #Laboratory
Laboratory Evaluation of Patients for Thyroid Disease 
Hyperthyroidism:
 • Graves disease - TSH low; free T4
Laboratory Evaluation ... high; in some cases ... , T3 is elevated ... ; TRAbs or TSI elevated ... #hyperthyroid #differential
ANTI-MDA5 DERMATOMYOSITIS

Cutaneous manifestations:
• Periorbital heliotrope (blue-purple) rash with edema
• Erythematous rash on the face, or the
Dermatomyositis • Fever ... • Blood tests: Elevated ... no significant elevation ... or GGT, without elevated ... ILD worsens Decreased
Heat Illnesses and Heat Stroke - Differential Diagnosis Framework

Heat Cramps:
 • Muscle pain or spasm -
Heat Stroke - Differential ... sweaty skin - Decreased ... normal/mildly elevated ... acidosis - CPK elevation ... #diagnosis #causes
CNS Infections - Viral Encephalitis and Bacterial Meningitis - Differential Diagnosis Framework

Viral Encephalitis:
MCC: Enteroviruses (e.g., coxsackievirus
• Headache • Fever ... pleocytosis • A mildly elevated ... /L) • Mildly decreased ... pleocytosis with an elevated ... meningeal signs (fever
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
Rhabdomyolysis - Differential ... Management Summary Causes ... Muscle swelling - Fever ... ULN • AST/ALT Elevation ... vasoconstriction → decreased