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diagnosis betadglucan causes fungal galactomannan lactate acidosis aspergillus biomarkers bronchiectasis cardiology classification comparison dehydrogenase dm2 elevated falsepositives hba1c hematology hgba1c
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
Elevation and Reduction ... Elevation == Decreased ... • Asplenia Laboratory ... HbA1c #HgbA1c #Laboratory ... Diagnosis #DM2 #Differential
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory ... Mild-to-moderate decrease ... Platelet count - Decreased ... Mild-to-moderate elevation ... WBC count and differential
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
breakthrough IFI in HM • False ... BAL GM does not differentiate ... - Sensitivity decreased ... recipients, CGD pts • False ... post-2010 almost never
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives 1,3-Beta-D-Glucan • Cell wall component of many fungi
Specificity and False ... BAL samples • False ... in BAL does not differentiate ... post-2010 almost never ... FalsePositives #Laboratory
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Dehydrogenase (LDH) - Differential ... myocarditis, rheumatic fever ... Idiosyncratic LDH Elevation ... Dehydrogenase #Elevated #differential ... #diagnosis #Laboratory
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Causes of Lactate Elevation ... Lactic Acidosis - Differential ... - assess other laboratory ... muscle use • Decreased ... #Differential #
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Rhabdomyolysis - Differential ... Muscle swelling - Fever ... ULN • AST/ALT Elevation ... vasoconstriction → decreased ... Rhabdomyolysis #Differential
Bronchiectasis - Summary What? • Bronchiectasis is derived from the Greek words bronckos meaning airway and ectasis meaning
run-down or tired • Fevers ... Superimposed infection - increase ... Bronchoscopy Laboratory ... Bronchiectasis #pulmonary #differential
Palpitations - Differential Diagnosis Framework What? • It is an unpleasant awareness or sensation that the heart is
Palpitations - Differential ... ECG • Limited laboratory ... Electrolyte imbalance • Fever ... tachycardia due to decreased ... Palpitations #Cardiology #Differential
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