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diagnosis causes lactate acidosis hematology lactic workup acute algorithm bronchiectasis cardiology classification criticalcare dehydrogenase dm2 elevated false hba1c hemolytic hgba1c
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
• Asplenia Laboratory ... Reduction == Increase ... • Hemolytic anemia ... #Increase #Decrease ... Diagnosis #DM2 #Differential
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory ... Mild-to-moderate decrease ... result in severe anemia ... Mild-to-moderate elevation ... WBC count and differential
Causes of Hyperferritinemia - Differential Diagnosis Ferritin > 1000 Ferritin is the storage form of iron. Increased hepcidin
Increased hepcidin ... Decreased hepcidin ... levels will cause increased ... Sideroblastic anemia ... extreme ferritin elevation
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... without platelet decrease ... bartonella (oroya fever ... #Differential #
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Dehydrogenase (LDH) - Differential ... myocarditis, rheumatic fever ... Idiosyncratic LDH Elevation ... Dehydrogenase #Elevated #differential ... #diagnosis #Laboratory
Lactic Acidosis - Differential Diagnosis Framework Type A: Impaired O2 Delivery (DO2) • Decreased O2 Delivery: Hypotension
Lactic Acidosis - Differential ... Delivery (DO2) • Decreased ... Shock, Severe Anemia ... Compartment Syndrome • Increased ... Pain / Exercise, Fever
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Lactic Acidosis - Differential ... - assess other laboratory ... Circulatory System • Increased ... muscle use • Decreased ... 30mmHg) - Severe anemia
Causes of Hypokalemia Transcellular Shifts: - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
- Alkalosis, Increased ... periodic paralysis Decreased ... , Heat stroke, Fever ... megaloblastic anemia ... Hypokalemia #Causes #differential
Acute Retroviral Syndrome Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection •
Headache (45%) • Fever ... - Liver enzyme elevation ... T-cell count can decrease ... enzymes ↑ • Mild anemia
Bronchiectasis - Summary What? • Bronchiectasis is derived from the Greek words bronckos meaning airway and ectasis meaning
run-down or tired • Fevers ... Superimposed infection - increase ... Bronchoscopy Laboratory ... Bronchiectasis #pulmonary #differential
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