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diagnosis acidosis hematology lactate lactic algorithm causes classification criticalcare dm2 false hba1c hemolytic hgba1c reduction testing thromboticthrombocytopenicpurpura ttp typea typeb
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
== Decreased RBC ... Reduction == Increase ... • Hemolytic anemia ... #Increase #Decrease ... Diagnosis #DM2 #Differential
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory ... Mild-to-moderate decrease ... Mild-to-moderate elevation ... WBC count and differential ... ThromboticThrombocytopenicPurpura #Diagnosis #Workup
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... without platelet decrease ... bartonella (oroya fever ... Diagnosis #Algorithm #workup
Lactic Acidosis - Differential Diagnosis Framework Type A: Impaired O2 Delivery (DO2) • Decreased O2 Delivery: Hypotension
Lactic Acidosis - Differential ... Shock, Severe Anemia ... Compartment Syndrome • Increased ... Pain / Exercise, Fever ... Beta-Agonists, ↑ work
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Lactic Acidosis - Differential ... - assess other laboratory ... Circulatory System • Increased ... muscle use • Decreased ... 30mmHg) - Severe anemia
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