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diagnosis differential hepatology lfts causes transaminitis aflp aih autoimmune chemistry comparison creactiveprotein crp dehydrogenase disease enzymes heat heatstroke hellp hscrp
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... (LFTs) Elevation ... specific for the liver ... #FunctionTest # ... LFTs #Elevation
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Check Acute viral hepatitis ... specificity to elevated ... Bilirubin - +/- elevation ... or amyloid: • Elevation ... Enzyme Elevation
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
Mild jaundice, Elevated ... to 10-20-fold elevation ... Syndrome (Hemolysis, Elevated ... to 10-20-fold elevation ... hepatology #obstetrics #hepatitis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... specificity to elevated ... Bilirubin - +/- elevation ... function may be abnormal ... Enzyme Elevation
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
disease to acute liver ... hepatocellular pattern of liver ... IgG typically elevated ... upper limit of normal ... (rare) - IgG Elevation
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Elevated Lactate ... RBCs, muscle, liver ... upon damage • Normal ... It can remain elevated ... Idiosyncratic LDH Elevation
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Differential Diagnosis Algorithm ... disease US — Normal ... • Alcoholic hepatitis ... Differential #Diagnosis #Algorithm
C-REACTIVE PROTEIN Discovered by Tillett & Francis in 1930. First identified as a substance in the serum
synthesized by the liver ... or minor elevation ... mg/L: Moderate elevation ... 10.0 mg/L: Marked elevation ... 50.0 mg/L: Severe elevation
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
Abnormal liver function ... tests algorithm ... initial response to abnormal ... magnitude of enzyme elevation ... #Algorithm #Hepatology
Heat Illnesses and Heat Stroke - Differential Diagnosis Framework Heat Cramps: • Muscle pain or spasm -
Muscles, Kidneys, Liver ... - Core temp normal ... /mildly elevated ... tissue damage (AKI, Liver ... acidosis - CPK elevation
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