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diagnosis differential hepatology causes lfts acute injury transaminitis abnormal aflp chemistry chronic comparison dehydrogenase disease elevated enzymes fatigue hellp hepatomegaly
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... (LFTs) Elevation ... specific for the liver ... #FunctionTest # ... LFTs #Elevation
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... vein: Budd-chiari syndrome ... Bilirubin - +/- elevation ... • Gilbert's syndrome ... Enzyme Elevation
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
• Infectious: Hepatitis ... NAFLD, Autoimmune hepatitis ... obstruction, HELLP Syndrome ... Sepsis, Viral Hepatitis ... Causes #Acute #algorithm
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Check Acute viral hepatitis ... Check Acute viral hepatitis ... Bilirubin - +/- elevation ... Enzyme Elevation ... • Gilbert's syndrome
Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
Differential Diagnosis Algorithm ... Non-Malignant • Fatty Liver ... • Budd-Chiari Syndrome ... Infectious • Hepatitis ... Differential #Diagnosis #Algorithm
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
Liver Disease in ... to 10-20-fold elevation ... necrosis HELLP Syndrome ... to 10-20-fold elevation ... hepatology #obstetrics #hepatitis
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
RBCs, muscle, liver ... • Ischemic hepatitis ... • Tumor lysis syndrome ... polyangiitis • Behçet's syndrome ... Idiosyncratic LDH Elevation
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Differential Diagnosis Algorithm ... Renal Failure • Liver ... Epstein-Barr Virus • Hepatitis ... Chronic Fatigue Syndrome ... Differential #Diagnosis #Algorithm
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
Abnormal liver function ... tests algorithm ... presence of metabolic syndrome ... magnitude of enzyme elevation ... LFTs #Abnormal #Algorithm
Acute Retroviral Syndrome Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection •
Acute Retroviral Syndrome ... Hepatomegaly - Liver ... enzyme elevation ... subset counts ↓ • Liver ... infection • Viral hepatitis
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