6 results
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
to 10-20-fold elevation ... , no necrosis HELLP ... to 10-20-fold elevation ... and hemorrhage Acute ... diagnosis #icp #HELLP
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... Differential Diagnosis Algorithm ... • Hepatic vein: ... • Pregnancy: HELLP ... Enzyme Elevation
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Causes of Acute ... biliary obstruction, HELLP ... Vasculature • Hepatic ... Congestion/CHF • Hepatic ... #algorithm #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Bilirubin - +/- elevation ... - If both are normal ... replaced by non-hepatic ... or amyloid: • Elevation ... Enzyme Elevation
Commonly Observed Laboratory Findings in Hepatic / Liver Failure
 - Elevated conjugated and unconjugated bilirubin -
Laboratory Findings in Hepatic ... / Liver Failure ... ALT and AST - Elevations ... —100-fold with acute ... #LiverFailure #Hepatic
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework

LDH is a cytoplasmic enzyme present in tissues throughout
RBCs, muscle, liver ... upon damage • Normal ... lung injuries Hepatic ... hepatitis • Acute ... Idiosyncratic LDH Elevation