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diagnosis hepatology differential alkaline alp injury phosphatase ascites cholangitis cirrhosis dili druginduced hepatitis hepatomegaly hyophosphatasia lfts low pbc transaminitis workup
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... (LFTs) Elevation ... ALP - Biliary ... #FunctionTest # ... LFTs #Elevation
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
Differential Diagnosis Algorithm ... Highest • Bone • Liver ... Intestine - Other causes ... - Drugs - Primary ... biliary Cholangitis
Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
Differential Diagnosis Algorithm ... Non-Malignant • Fatty Liver ... Biliary Cirrhosis ... Differential #Diagnosis #Algorithm ... #Causes #Hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... for alternative causes ... obstruction, Primary ... biliary cholangitis ... , Primary sclerosing
Causes of Ascites - Differential Diagnosis Algorithm Portal Hypertension - Prehepatic: • Portal vein thrombosis • Splenic
Causes of Ascites ... Differential Diagnosis Algorithm ... disease • Acute liver ... failure • Primary ... biliary cholangitis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... Vascular Causes ... Bilirubin - +/- elevation ... Enzyme Elevation ... differential #diagnosis #algorithm
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Primary Biliary ... 65 years PBC Pathophysiology ... intralobular bile ducts causes ... cholestasis → Cirrhosis/Liver ... or higher • Liver
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
synthesized in: liver ... collection with EDTA Pathophysiology ... eliminated • Elevation ... phosphate &/or • Elevation ... of urinary PEA
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