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differential hematology management arthritis classification druginduced leukemia msk pain sle vasculitis antiphospholipid apls apml approach arthropathies arthropathy ascites associations autoantibodies
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
ALL Symptoms: ... bone pain, fever, joint ... • Tumor lysis syndrome ... ) CLL Symptoms: ... #Oncology #Diagnosis
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Lymphoma (HCV) • CLL ... Scleromyxedema (CNS+GI+CVS+joints ... to cold IgG • Lupus ... #Differential #Diagnosis ... #Oncology
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
• Lupus (SLE): ... ANA (anti-nuclear ... Polymerase Ill ... #diagnosis #associations ... #table
Joint Disorders - Differential Diagnosis Algorithm Monoarthritis • Septic • Crystalline - Gout
- Differential Diagnosis ... Algorithm Monoarthritis ... of Lumbar Spine and ... arthritis - (Reiter’s syndrome ... should have other symptoms
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
Pain - Diagnostic ... spondyloarthropathies, lupus ... Send for cell count ... #rheumatology # ... approach #workup
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... Diagnosis: • ... and other C Cell ... #workup #oncology ... #hematology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Epidemiology: -10% of all ... Constitutional symptoms ... sle #comparison #table ... #rheumatology # ... diagnosis #management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... Arthritis: • Joint ... arthropathy • 90% joints ... : • Symptoms limited ... #Rheumatology
Suggested diagnostic approach to a patient with exudative ascites. Low ascitic fluid protein should direct practitioners
out nephrotic syndrome ... be done at this point ... only about 15% of all ... obstruction, nephrotic syndrome ... #workup #algorithm
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Presentation: Systemic Symptoms ... CRP GCA (Giant Cell ... • Progressive symptoms ... Palpable purpura, joint ... #Rheumatology
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