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diagnosis differential druginduced management anemia antiphospholipid apls arthritis classification comparison dil disease erythematosus glomerulonephritis hemolytic hypercoagulable laboratory polycythemia progressive rapidly
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Complement: Post-strep GN ... , Lupus Nephritis ... • Limited to Kidney ... Glomerulonephritis #Vasculitis ... #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
vs SLE Drug Induced ... myalgia, serositis, Kidney ... • Immunologic Workup ... • Immunologic Workup ... #table #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Non-autoimmune rheumatologic ... C4) • ds-DNA: Kidney ... • Kidney biopsy ... Erythematosus #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... inflammation Others: • Lupus ... such as systemic lupus ... , and SLE) • Urinalysis ... differential #diagnosis #rheumatology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Differential Diagnosis Algorithm ... genotypes): SS, SC, SE ... cardiac valve, vasculitis ... #workup #hematology ... #testing
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Rapidly progressing GN ... diseases, such as SLE ... musculoskeletal systems • Kidneys ... • Pauci immune GN ... Differential #Diagnosis #Rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... joint • Systemic lupus ... - CCP antibody testing ... Arthritis #laboratory #workup ... #Rheumatology
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Differential Diagnosis Algorithm ... Better call hematology ... some time, let’s see ... oxygen sensing (at kidneys ... #workup #hematology
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm INDICATIONS FOR TESTING: • Vascular thrombosis
Hypercoagulable Workup ... Algorithm INDICATIONS ... : • Lupus Anticoagulant ... #Algorithm #diagnosis ... #hematology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
Drug Induced Lupus ... myalgia, serositis, Kidney ... is rare in DIL, SCLE-DIL ... • Immunologic Workup ... #DIL #rheumatology
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