Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm
INDICATIONS FOR TESTING:
• Vascular thrombosis
- 1 or more clinical episodes of arterial, venous, or small-vessel thrombosis
• Unexplained pregnancy loss defined as:
- 1 or more unexplained deaths of a morphologically normal fetus beyond the 10th week of gestation
- 1 or more premature births of a morphologically normal neonate before the 34th week of gestation due to eclampsia, preeclampsia, or placental insufficiency
- 3 or more unexplained, consecutive, spontaneous abortions before the 10th week of gestation, and with maternal anatomic or hormonal abnormalities and paternal and maternal chromosomal causes excluded
Testing:
• Lupus Anticoagulant Reflexive Panel
• Cardiolipin Antibodies, IgG and IgM
• Beta-2 Glycoprotein 1 Antibodies, IgG and IgM
• Phosphatidylserine and Prothrombin Antibodies, IgG and IgMa
• Phosphatidylserine Antibodies, IgG and IgMa
• Prothrombin Antibody, IgGa
• Cardiolipin Antibody, IgA
• Beta-2 Glycoprotein 1 Antibody, IgA
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