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diagnosis differential vasculitis classification anca antibodies antineutrophil antinuclear cryoglobulinemia cryoglobulins glomerulonephritis hematology limping monoclonal nwb paraproteinemias pathway pediatrics peds progressive
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... Antibody) and ANCA ... antibodies) • Systemic ... lupus erythematosus ... antibodies #diagnosis #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... Complement: Post-strep GN ... , Lupus Nephritis ... involvement: Anti-GBM Disease ... #rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... to cold IgG • Lupus ... Sneddon-Wilkinson disease ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology
THE LIMPING OR NON-WEIGHT BEARING CHILD PATHWAY RED FLAGS - In all cases there are specific markers which
NON-WEIGHT BEARING CHILD ... FLAGS - In all cases ... guidelines General - Systemic ... Rheumatology ... #Limping #NWB #Algorithm
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... often causes arthritis ... Others: • Lupus ... LFT • ESR • ANA ... differential #diagnosis #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... • Autoimmune diseases ... cytoplasmic antibody ... lupus erythematosus ... classification #rheumatology
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