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diagnosis management differential druginduced hcq sle vasculitis adverseeffects algorithm benefits classification comparison dil glomerulonephritis levels measurement progressive rapidly risks rpgn
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
Hydroxychloroquine ... Lupusreference #Hydroxychloroquine ... Measurement #SLE #rheumatology ... #pharmacology # ... levels #lupus #management
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... Complement: Post-strep GN ... , Lupus Nephritis ... diagnosis #algorithm #rheumatology
Hydroxychloroquine - Risks and Benefits in Lupus Benefits: ↓ Disease activity, ↓ Flare, ↓ Damage, ↓ Corticosteroid dose,
Hydroxychloroquine ... and Benefits in Lupus ... Risks #Benefits #Lupus ... #pharmacology # ... #sideeffects #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Drug Induced Lupus ... cases, drug-dependent ... Discontinuation of causal ... drug +++, Hydroxychloroquine ... comparison #table #rheumatology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
Drug Induced Lupus ... Epidemiology: -10% of all lupus ... Discontinuation of causal ... drug +++, Hydroxychloroquine ... #DIL #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... tract, and often causes ... inflammation Others: • Lupus ... such as systemic lupus ... differential #diagnosis #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... Membranoproliferative GN ... Nephrogenic DI Hematologic ... lubricants • Pharmacologic ... Sjogrens #Syndrome #Rheumatology
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