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diagnosis hematology algorithm aptt coagulation prolonged pt vasculitis anemia antiphospholipid apls bleeding bruising classification elevatedmcv glomerulonephritis hemostasis hypercoagulable macrocytic macrocytosis
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... Complement: Post-strep GN ... , Lupus Nephritis ... Purpura Anti-GBM antibodies ... diagnosis #algorithm #rheumatology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Volume (MCV) - Differential ... B12 - Anti-IF Antibodies ... Deficiency - Abnormal ... #Hematology
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Rash - Differential ... deficiency - Abnormal ... Autoimmune Vasculitis (lupus ... #dermatology #physicalexam
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... antiphospholipid antibodies ... amyloidosis #Abnormal ... #diagnosis #differential ... #hematology #coagulation
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... antiphospholipid antibodies ... antiphospholipid antibodies ... #diagnosis #differential ... #hematology #coagulation
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
of Hemostasis - Differential ... inhibitor and lupus ... Willebrand syndrome • Lupus ... discern these causes ... #Diagnosis #Hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... tract, and often causes ... such as systemic lupus ... C-ANCA) pattern: antibodies ... #diagnosis #rheumatology
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm INDICATIONS FOR TESTING: • Vascular thrombosis
morphologically normal ... morphologically normal ... maternal chromosomal causes ... excluded Testing: • Lupus ... Algorithm #diagnosis #hematology
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