6 results
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
Complement: Post-strep GN ... , Lupus Nephritis ... , Cryoglobulinemia ... Glomerulonephritis #Vasculitis ... diagnosis #algorithm #rheumatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Cryoglobulinemia ... (e.g. systemic lupus ... diagnosis #types #classification ... #rheumatology # ... vasculitis
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
rapidly progressing GN ... such as systemic lupus ... LFT • ESR • ANA ... differential #diagnosis #rheumatology ... #classification
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
& Cryoglobulinemic ... Autoimmunity: • -MM/WM: Vasculitis ... (Cryoglobulinemic ... to cold IgG • Lupus ... Paraproteinemias #Hematology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
findings (ANA, ... Skin Disease Classification ... Non-autoimmune rheumatologic ... Chronic B-cell activation ... Erythematosus #Diagnosis #Rheumatology
Monoclonal Gammopathy of Renal Significance (MGRS)

MGRS
• MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
does not meet criteria ... guide subtype classification ... Complement pathway activation ... formation causing vasculitis ... , cryoglobulinemic