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diagnosis differential monoclonal algorithm cryoglobulinemia cryoglobulins erythematosus gammopathy glomerulonephritis hematology management mgrs myelitis neurology paraproteinemias progressive rapidly renal rpgn significance
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
Classification of ... Vasculitis Vasculitis ... vasculitis ... - systemic lupus ... #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Vasculitis and Vasculitides ... rapidly progressing GN ... LFT • ESR • ANA ... differential #diagnosis #rheumatology ... #classification
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Complement: Post-strep GN ... , Lupus Nephritis ... (C-ANCA): GPA > ... Glomerulonephritis #Vasculitis ... diagnosis #algorithm #rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Autoimmunity: • -MM/WM: Vasculitis ... Hypergammaglobulinemic macular Vasculitis ... to cold IgG • Lupus ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• IgA vasculitis ... Hypersensitivity vasculitis ... • Vasculitis ... #rheumatology # ... vasculitis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Skin Disease Classification ... vasculitis, rheumatoid ... • Mesenteric vasculitis ... inflammation Cutaneous Vasculitis ... Chronic B-cell activation
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
• Excessive activation ... Diagnostic Criteria ... zoster, West Nile virus ... Herpes simplex virus ... - Sjogren - Vasculitis
Monoclonal Gammopathy of Renal Significance (MGRS) MGRS • MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
does not meet criteria ... guide subtype classification ... Complement pathway activation ... formation causing vasculitis ... immunotactoid GN
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