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diagnosis differential syndrome druginduced arteritis behcet classification comparison dil disease erythematosus gca giantcell hematology hemophagocytic hlh indications lymphohistiocytosis macrophage mas
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Polyarteritis Nodosa (PAN ... ), ANCA associated ... (RA), Systemic lupus ... erythematosus (SLE ... Differential #Diagnosis #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Constitutional symptoms, Arthritis ... Workup: - ANA ... Workup: - ANA ... #table #rheumatology ... #diagnosis #management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Non-autoimmune rheumatologic ... : • Joint pain ... Chronic B-cell activation ... Erythematosus #Diagnosis #Rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... erythematosus [SLE ... Treatment: • Corticosteroids ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
Treatment of giant cell arteritis (GCA) 1st Line Strategy - GC 0.7 mg/kg/day, except for: • Aortitis
cell arteritis ... except for: • Aortitis ... #Management #Relapses ... #Indications #rheumatology ... #2ndline
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... claudication, aortitis ... LFT • ESR • ANA ... SLE) • Urinalysis ... differential #diagnosis #rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
: SLE, Reactive ... Arthritis, AS Treatment ... Nonsurgical abdominal pain ... Syndrome #diagnosis #management ... signs #symptoms #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... Infections+++: Virus ... Autoimmune diseases: SLE ... Lymphohistiocytosis #diagnosis #management ... #rheumatology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
Constitutional symptoms, Arthritis ... is rare in DIL, SCLE-DIL ... Workup: - ANA ... #DIL #rheumatology ... #management
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
• Excessive activation ... or without back pain ... Disorders: - SLE ... Transverse Myelitis Treatment ... Myelitis #diagnosis #management
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