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differential vasculitis ild lung algorithm associations causes classification cold connectivetissuediseases ctild druginduced eosinophilic glomerular glomerulonephritis hematology interstitial lungdisease management microscopy
Approach to Eosinophilic Lung Diseases • Acute Eosinophilic Pneumonia (< 1 wk) - ~30yo, M; Recent
Lung Diseases ... loss, malaise • Allergic ... #pulmonary #differential ... #diagnosis #comparison ... #table #eosinophilia
Connective tissue disease-associated interstitial lung diseases LIP: lymphoid interstitial pneumonia. NSIP: nonspecific interstitial pneumonia. OP: organizing pneumonia.
SLE : systemic lupus ... LungDisease #CTILD #Diagnosis ... #Differential #Comparison ... #Table #Pulmonary ... #Rheumatology #
Interstitial Lung Diseases (ILD) Exposure-Related ILD (a.k.a. extrinsic allergic alveolitis): • Hypersensitivity pneumonitis, Farmer's lung, Bird
a.k.a. extrinsic allergic ... Polymyositis-dermatomyositis, Lupus ... polyangiitis, Eosinophilic ... syndrome) • Eosinophilic ... #ILD #diagnosis
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Complement: Post-strep GN ... , Lupus Nephritis ... With associated pulmonary ... #differential #diagnosis ... #algorithm #rheumatology
Summary of characteristic abnormalities of selected glomerular diseases Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
/nephritis • Lupus ... Post-infectious GN ... • Membranous GN ... nephrology #pathology #comparison ... #table #diagnosis
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... to cold IgG • Lupus ... Sneddon-Wilkinson disease ... Episodic angioedema+eosinophilia ... #Differential #Diagnosis
Cold Urticaria Prevalence - 0.05% in the population Disease onset - Mostly 2nd to 4th decades of life Causes
Disorientation, vertigo Diagnostic ... neutrophils and eosinophils ... Cold #Urticaria #diagnosis ... #rheumatology # ... comparison #table
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
- Differential Diagnosis ... Vasculitis Differential Diagnosis ... progressive) EGPA (Eosinophilic ... Polyangiitis): • Eosinophilia ... #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... • EGPA: - Eosinophilia ... inflammation Others: • Lupus ... such as systemic lupus ... #rheumatology #
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Drug Induced Lupus ... Evolution: Chronic disease ... #sle #comparison ... #table #rheumatology ... #diagnosis #management
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