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amiodarone apml differentiation encephalopathy fungal hematology infectiousdiseases mycoses neurology oncology pres pulmonary reversible toxicity toxicology
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
Etiology: • Pathophysiology ... Neurological symptoms ... : Acute onset 2 ... Reversible course Differential ... #diagnosis #management
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Pathophysiology ... endothelial damage • Induce ... : >3 symptoms, or ... Diagnosis: Infection ... #management #hematology
Amiodarone Induced Lung Toxicity Summary Who? • 5% of patients • Dose ≥ 400 mg per day How? Possible
toxicity (e.g., acute ... respiratory distress syndrome ... Pleuritic chest pain ... failure - Infectious ... #management #Toxicology
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
Pulmonary 3) Abdominal ... , chest pain • ... yeast • At risk: AIDS ... Aspergillosis Pathophysiology ... #Management #Infections
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