95 results
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Pathophysiology Gitelman ... Hypokalemia Metabolic alkalosis ... dr_missyhanna #Gitelman
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
Primary Metabolic Alkalosis ... Bartter Syndrome, Gitelman ... Primary #Metabolic #Alkalosis
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... cotransporter • Gitelman's ... hypomagnesemia • Metabolic alkalosis ... Hypochloremic metabolic alkalosis ... Pseudo Bartter-Gitelman
Metabolic Alkalosis - Differential Diagnosis Algorithm - Urinary Chloride
 • Cl- responsive metabolic alkalosis
Metabolic Alkalosis ... responsive metabolic alkalosis ... resistant metabolic alkalosis ... Bartter syndrome, Gitelman ... use #Metabolic #Alkalosis
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Primary Metabolic Alkalosis ... Bartter Syndrome, Gitelman ... aldosteronism #Metabolic #Alkalosis
Approach to Elevated Bicarbonate (HCO3)
Risk Factors for Hypercapnea? (Hx of COPD, OSA, sedative use, CNS/muscular disorders?)
(+)
Likely Metabolic Alkalosis ... Barter, or Gitelman ... Elevated #metabolic #alkalosis
Causes of Metabolic Alkalosis - Differential Diagnosis
Chloride depletion syndromes
 • Gastrointestinal losses
    -
Causes of Metabolic Alkalosis ... syndrome - Gitelman ... #Metabolic #Alkalosis
Causes of Metabolic Alkalosis - Differential Diagnosis Algorithm
Urine chloride < 20 mmol/l - Chloride responsive (Chloride
Causes of Metabolic Alkalosis ... Bartter's Syndrome, Gitelman's ... #Metabolic #Alkalosis
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
Metabolic Alkalosis ... responsive metabolic alkalosis ... resistant metabolic alkalosis ... Bartter syndrome, Gitelman ... #Metabolic #Alkalosis
Gitelman Syndrome - Diagnosis and Workup
Blood Work:
 - Hypokalemia
 - Hypomagnesemia
 - Metabolic Alkalosis
 - Elevated
Gitelman Syndrome ... Hypomagnesemia - Metabolic Alkalosis ... dr_missyhanna #Gitelman