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management apml differentiation endocrinology evaluation hematology oncology perioperative preop preoperative stratification syndrome treatment
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook Clinical Presentation: • Classic Acromegaly: frontal
Acromegaly - Diagnosis ... decade → peripheral/acral ... Insulin resist + DM ... peripheral (bronchial/abdominal ... Pegvisomant) ± D2
Preoperative Risk Evaluation Major Pre-Op Questions: 1. Does the patient have any modifiable risk factors that could be
Insulin dependent DM ... Intraabdominal - Orthopedic ... undergoing AAA or upper abdominal ... CARP, DECREASE V trials ... stratification #diagnosis
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
• Triggers: ATRA ... treatment Pathophysiology ... Attempt if high risk ... day vs. 2.5 mg/m2 ... or 15 days of ATRA
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