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diagnosis management hematology hemophagocytic hlh kawasaki lymphohistiocytosis pediatrics peds rheumatology ddxof hemeonc incomplete macrophage mas perioperative preop preoperative risk stratification
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... IFN-y) → Excessive activation ... • Clinical: fever ... , Hb), Hepatic dysfunction ... inhibitors under evaluation
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... • Periodic fever ... nervous system (CNS) dysfunction ... Histopathologic criteria ... MAS #Macrophage #Activation
Evaluation of suspected incomplete Kawasaki Disease 1. AHA consensus recommendations 2. Infants ≤6 months old on day ≥7
Evaluation of suspected ... incomplete Kawasaki Disease ... old on day ≥7 of fever ... purposes of this algorithm ... within 10 d of fever
Algorithm for the Evaluation of Kawasaki and Incomplete Kawasaki Disease: Diagnosis * Fever >5d * Criteria (4/5) -
Algorithm for the ... Evaluation of Kawasaki ... Incomplete Kawasaki Disease ... Diagnosis * Fever ... #Algorithm #Ddxof
Preoperative Risk Evaluation Major Pre-Op Questions: 1. Does the patient have any modifiable risk factors that could be
Preoperative Risk Evaluation ... or family - Ever ... Performance thorough ... event, follow ACC algorithm ... or LV dysfunction
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
cytopenias and organ dysfunction ... , organ dysfunction ... ▪ Autoimmune diseases ... Diagnostic Criteria ... of 8 HLH-2004 criteria
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