13 results
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
antibodies bind to mast ... degranulation of mast ... cellular antigen, leading ... Complement activation ... Hypersensitivity #Types #Classification
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation ... IL-1 and IL-6, leading ... nervous system (CNS) dysfunction ... #Macrophage #Activation ... Syndrome #Diagnosis #Management
SEPSIS AND SEPTIC SHOCK

DEFINITION AND PATHOPHYSIOLOGY
 • Sepsis: Life-threatening organ dysfunction due to a dysregulated host
Life-threatening organ dysfunction ... cytokines, complement activation ... INITIAL MANAGEMENT ... ADVANCED MANAGEMENT ... Shock #Diagnosis #Management
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Allergen-specific lgE causes mast-cell ... cell antigens, leading ... to complement activation ... allergy #table #classification
Shock Classification
Shock Definition: State of cellular and tissue hypoxia due to: reduced oxygen delivery, increased oxygen
Shock Classification ... END-ORGAN DYSFUNCTION ... Hemorrhagic → leading ... water #Shock #Classification ... Types #diagnosis #management
Shock Types - Classification
State of cellular and tissue hypoxia due to: reduced oxygen delivery, increased oxygen
Shock Types - Classification ... END-ORGAN DYSFUNCTION ... Hemorrhagic → leading ... water #Shock #Classification ... types #diagnosis #management
Pheochromocytoma - Diagnosis and Management Summary
10 percent rule = 10% of pheochromocytomas are extra-adrenal, multiple, bilateral,
Diagnosis and Management ... and other organ dysfunction ... blood pressure management ... blood pressure management ... adrenoceptors, potentially leading
Hepatic Encephalopathy - Diagnosis and Management Summary
Definition:
 • Alteration in brain function manifested by neuropsychiatric symptoms
Diagnosis and Management ... building muscle mass ... Encephalopathy #Grading ... #Classification ... #Diagnosis #Management
Preoperative Risk Evaluation

Major Pre-Op Questions:
1. Does the patient have any modifiable risk factors that could be
Performance thorough ... with valvular dysfunction ... or LV dysfunction ... stress testing may ... medical and surgical management
Hypersensitivity: Definitions
 • Type I - Production of lgE Abs that bind to harmless allergens and
allergens and activate mast ... degranulation, leading ... immune reaction, leading ... because T-Cell activation ... Reactions #Types #Classification