7 results
Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
• Endogenous reactivation ... characteristic features Clinical ... Tuberculin skin test ... Inhibitor: • Risk of reactivation ... with TST or IGRA
Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
• Endogenous reactivation ... characteristic features Clinical ... Tuberculin skin test ... Inhibitor: • Risk of reactivation ... with TST or IGRA
Tuberculosis Testing

LATENT TB
• LTBI is diagnosed when an asymptomatic patient has a positive TST or IGRA
Testing LATENT TB ... result with no clinical ... decrease the risk for reactivation ... IGRA/QuantiFERON-TB ... age ACTIVE TB
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
• Excessive activation ... Transverse Myelitis - Clinical ... negative, MOG-IgG test ... Herpes zoster, West ... , Hep A/B/CMV, TB
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation ... fever syndromes Clinical ... Fever is the main clinical ... nervous system (CNS) dysfunction ... Liver function tests
SEPSIS AND SEPTIC SHOCK

DEFINITION AND PATHOPHYSIOLOGY
 • Sepsis: Life-threatening organ dysfunction due to a dysregulated host
Life-threatening organ dysfunction ... cytokines, complement activation ... CLINICAL RECOGNITION ... CLINICAL FEATURES ... and molecular tests
Preoperative Risk Evaluation

Major Pre-Op Questions:
1. Does the patient have any modifiable risk factors that could be
Performance thorough ... determine if stress test ... with valvular dysfunction ... or LV dysfunction ... Change in clinical