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diagnosis management hemophagocytic hlh lymphohistiocytosis rheumatology hemeonc macrophage mas perioperative preop preoperative risk stratification summary syndrome treatment
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... nervous system (CNS) dysfunction ... Histopathologic criteria ... MAS #Macrophage #Activation ... Diagnosis #Management #Hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... IFN-y) → Excessive activation ... • Clinical: fever ... , Hb), Hepatic dysfunction ... inhibitors under evaluation
Preoperative Risk Evaluation Major Pre-Op Questions: 1. Does the patient have any modifiable risk factors that could be
Preoperative Risk Evaluation ... or family - Ever ... Performance thorough ... event, follow ACC algorithm ... or LV dysfunction
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
cytopenias and organ dysfunction ... , organ dysfunction ... Diagnostic Criteria ... of 8 HLH-2004 criteria ... Diagnosis #Management #Hematology
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