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diagnosis management hematology hemophagocytic lymphohistiocytosis rheumatology hemeonc macrophage mas perioperative preop preoperative risk stratification summary syndrome treatment
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... IFN-y) → Excessive activation ... • Clinical: fever ... , Hb), Hepatic dysfunction ... inhibitors under evaluation
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... lymphohistiocytosis (HLH ... nervous system (CNS) dysfunction ... Histopathologic criteria ... MAS #Macrophage #Activation
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
cytopenias and organ dysfunction ... , organ dysfunction ... Diagnostic Criteria ... -2004 criteria or ... Fever b.
Preoperative Risk Evaluation Major Pre-Op Questions: 1. Does the patient have any modifiable risk factors that could be
Preoperative Risk Evaluation ... or family - Ever ... Performance thorough ... event, follow ACC algorithm ... or LV dysfunction
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