GradingSystem performance testing algorithm hematology complement anemia cold extravascular

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Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
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Warm AIHA • Cold ... perfringens - Complement-Mediated ... • Cold AIHA ... immune-complex hemolytic anemia ... #Causes #Hematology

Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
1. Cold Agglutinins (CAD)
2. Donath-Landsteiner

• Symptoms of anemia ... Positive Coombs testing ... temperatures by fixing complement ... the RBCs causing intravascular ... #hematology #diagnosis

Hemolytic Anemia - Differential Diagnosis Algorithm
• Sickle cells - Consider sickle cell disease (diverse genotypes):

Hemolytic Anemia ... Differential Diagnosis Algorithm ... Agglutination - Cold ... #workup #hematology ... #testing

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