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diagnosis anemia differential hemolytic agglutinin causes disease extravascular hemolysis intravascular perioperative preop preoperative risk stratification workup
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Warm AIHA • Cold ... AIHA • Alloimmune ... perfringens - Complement-Mediated ... • Cold AIHA ... #Causes #Hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Viral infection, autoimmune ... Positive Coombs testing ... CLL (older) • Autoimmune ... temperatures by fixing complement ... hemolytic #anemia #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Differential Diagnosis Algorithm ... Agglutination - Cold ... elliptocytosis, autoimmune ... #workup #hematology ... #testing
Preoperative Risk Evaluation Major Pre-Op Questions: 1. Does the patient have any modifiable risk factors that could be
Preoperative Risk Evaluation ... Performance thorough ... event, follow ACC algorithm ... surgery Stress Testing ... preoperative stress testing
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