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diagnosis differential anemia causes hemolytic agglutinin disease evaluation extravascular hemolysis immunecompromised immunocompromised intravascular perioperative preop preoperative risk stratification workup
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Warm AIHA • Cold ... • PK deficiency ... perfringens - Complement-Mediated ... • Cold AIHA ... #Causes #Hematology
Complement Deficiency Testing Algorithm • Normal CH50 and AH50 AND High suspicion for complement deficiency •
Complement Deficiency ... Testing Algorithm ... deficiency • Low ... #Deficiency #Testing ... #Algorithm #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Differential Diagnosis Algorithm ... Agglutination - Cold ... bartonella (oroya fever ... #workup #hematology ... #testing
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Positive Coombs testing ... post infectious setting ... temperatures by fixing complement ... Symptoms: High fevers ... hemolytic #anemia #hematology
Causes of Fever in the Immunocompromised Host - Differential Diagnosis Algorithm Structural Defect - Asplenia/HypospIenism • Bacteremia/Septic
Causes of Fever ... Periodontal Disease Complement ... Deficiency • ... Infection #Fever ... #Causes #Hematology
Preoperative Risk Evaluation Major Pre-Op Questions: 1. Does the patient have any modifiable risk factors that could be
or family - Ever ... Performance thorough ... event, follow ACC algorithm ... surgery Stress Testing ... preoperative stress testing
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