GradingSystem performance testing algorithm hematology complement differential extravascular cold

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Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
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Hemolysis - Differential ... Diagnosis Algorithm ... Warm AIHA • Cold ... perfringens - Complement-Mediated ... #Hematology

Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
1. Cold Agglutinins (CAD)
2. Donath-Landsteiner

Positive Coombs testing ... younger pts) Differential ... temperatures by fixing complement ... the RBCs causing intravascular ... hemolytic #anemia #hematology

Hemolytic Anemia - Differential Diagnosis Algorithm
• Sickle cells - Consider sickle cell disease (diverse genotypes):

Hemolytic Anemia - Differential ... Diagnosis Algorithm ... Agglutination - Cold ... #workup #hematology ... #testing

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