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diagnosis differential clinical hematology causes algorithm oncology microscopy management pathology nephrology smear dermatology casts urine acute nejm pathophysiology syndrome treatment
Acute promyelocytic leukemia (blood). Typical morphologic features are bilobed ("butterfly") nuclei with dispersed chromatin, subtle to
promyelocytic leukemia ... overt cytoplasmic granules ... , and Auer rods. ... KyleBradleyMD #Auer ... promyelocytic #leukemia
Here are very large, immature myeloblasts with many nucleoli. A distincitve feature of these blasts is
a linear red "Auer ... of crystallized granules ... acute myelogenous leukemia ... Smear #Microscopy #Auer
A 37-year-old woman initially presented with pancytopenia and found to have leukopenia (2.1 × 103/μL) with
abundant cytoplasmic granules ... promyelocytic leukemia ... decreased secondary granules ... acute myeloid leukemia ... mixed lineage leukemia
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 Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Leukemias Overview ... , CLL Acute leukemias ... Chronic leukemia ... Age: 50-60 • Auer ... distinctive primary granules
T-LGL leukemia - T-CeIl Large Granular Lymphocytic Leukemia Clinical - Persistent (>6mo) lymphocytosis (2-20k) with proven clonality
T-LGL leukemia - ... T-CeIl Large Granular ... Lymphocytic Leukemia ... Predominantly leukemic ... #Lymphocytic #Leukemia
Examples of varying granular and granular/waxy mixed casts: A: coarse granular/broad-waxy (and surrounding white blood cells);
Examples of varying granular ... and granular/waxy ... casts: A: coarse granular ... /muddy brown granular ... #Granular #MuddyBrown
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
histamine in their granules ... Chronic myeloid leukemia ... Acute myeloid leukemia ... Acute basophilic leukemia
Auer Rods - Bone marrow aspiration revealed 5% blasts and 65% promyelocytes; many promyelocytes had prominent
Auer Rods - Bone ... had prominent Auer ... APL #AuerRods #Auer
Granular & “Muddy Brown” Casts on Urine Microscopy A. Finely granular cast B. slightly coarser granular cast
Granular & “Muddy ... Finely granular ... slightly coarser granular ... muddy brown (mb) granular ... #Granular #MuddyBrown
Signs and Symptoms of Acute Leukemia #Leukemia #Signs #Symptoms #Acute #Diagnosis #Oncology
Symptoms of Acute Leukemia ... #Leukemia #Signs
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