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liver lfts causes management transaminitis aclf chemistry chronic druginduced failure function hepatitis idiosyncratic induced interpretation liverenzymes rvalue tests
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Liver Injury (DILI ... symptoms of liver disease ... Idiosyncratic #differential ... #algorithm #gastroenterology ... #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
ACLF) Clinical Guidelines ... underlying liver disease ... Liver Injury (DILI ... #Hepatology #gastroenterology ... #management #diagnosis
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
• NAFLD • Cirrhosis ... Hepatopathy • Acute ... (>1000): • DILI ... (Drug-induced liver ... #Diagnosis #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Injury (DILI) - ... Algorithm DILI ... dechallenge • Acute ... #Diagnosis #Algorithm ... #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Diagnosis Algorithm ... • Cholestatic disease ... • Pancreatic cancer ... Others #LFTs #Hepatology ... #Diagnosis #Algorithm
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Diagnosis Algorithm ... hepatitis: < 1 • Cirrhosis ... #diagnosis #algorithm ... #hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Liver Injury - Differential ... , Recreational Drugs ... Pancreatic Pseudocyst, Cancer ... #Acute #algorithm ... #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
of cholestatic disease ... hepatitis: < 1 • Cirrhosis ... liver #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis
Myelodysplastic syndromes current treatment algorithm 2018. From Blood Cancer Journal, Published 24 May 2018 Myelodysplastic syndromes (MDS) are
current treatment algorithm ... clonal evolution to acute ... median age at diagnosis ... Network (NCCN) guidelines ... #algorithm #hematology
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