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differential causes liver management injury ascites lfts saag transaminitis aclf albumin alcoholic anemia approach cancer chemistry child chronic drug druginduced
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
ACLF) Clinical Guidelines ... underlying liver disease ... Liver Injury (DILI ... #Hepatology #gastroenterology ... #management #diagnosis
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
• NAFLD • Cirrhosis ... Hepatopathy • Acute ... Viral Hepatitis ... (>1000): • DILI ... #hepatology #transaminitis
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... symptoms of liver disease ... #differential #Diagnosis ... #algorithm #gastroenterology ... #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
) - Stepwise Diagnosis ... Algorithm DILI ... Alcohol-related liver disease ... dechallenge • Acute ... #Algorithm #hepatology
Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
- Differential Diagnosis ... Algorithm Malignant ... Hemochromatosis • Wilson's Disease ... Primary Biliary Cirrhosis ... #Hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential Diagnosis ... Algorithm Vascular ... • Iatrogenic: DILI ... : < 1 • Cirrhosis ... #algorithm #hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... - Differential Diagnosis ... , Acute biliary ... #Differential #Diagnosis ... #algorithm #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Algorithm Severe ... • Cholestatic disease ... • Alcoholic hepatitis ... Infiltrative • Cirrhosis ... Others #LFTs #Hepatology
Portal Hypertension - Differential Diagnosis Portal Pressure = the pressure difference between the pressure in the portal
- Differential Diagnosis ... /acute hepatitis ... • Infiltrative diseases ... Veno-occlusive disease ... #causes #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
of cholestatic disease ... Alcoholic liver disease ... : < 1 • Cirrhosis ... liver #chemistry #diagnosis ... #differential #Hepatology
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