69 results
Gustilo classification of open fractures #Diagnosis #EM #Ortho #Gustilo #Classification #Open #fractures
Gustilo classification ... Diagnosis #EM #Ortho #Gustilo
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH ... • Familial HLH ... Chediak-Higashi, Griscelli, Purtilo ... XLP) Acquired HLH ... Nicolas Taar #HLH
Menstrual Cycle Physiology: Ovarian Cycle – Brief Overview
LH and FSH are required for follicular development and
Brief Overview LH ... granulosa cells - LH ... following ovulation -> LH ... -> Inhibit FSH/LH ... MenstrualCycle #OvarianCycle
Menstrual Cycle Physiology: Ovarian Cycle – Ovulation Explained

Around Day 14, estrogen exerts sudden +++ positive feedback
understood) -> surge in LH ... production and release LH ... 36 hours after LH ... MenstrualCycle #OvarianCycle
Hemophagocytic Lymphohistiocytosis (HLH)
Clinical Features: Fever, Splenomegaly, Hepatomegaly, Lymphadenopathy, Confusion
Classic lab findings in HLH: ↑↑ ferritin, Anemia,
Lymphohistiocytosis (HLH ... lab findings in HLH ... Diagnostic Criteria for HLH ... consistent with HLH ... EricsMedicalLectures/ #HLH
Menstrual Cycle Physiology: Ovarian Cycle – Luteal Phase Explained
 • The LH surge can be thought
Explained • The LH ... Day 14 surge in LH ... GnRH, FSH, and LH ... • Decreased LH ... MenstrualCycle #OvarianCycle
Diagnostic Schema for Hyperferritinemia

Pearl: Diseases associated with extreme elevations: 
1. HLH 
2. Still's disease 
3. Systemic
HLH 2.
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Lymphohistiocytosis (HLH ... / Diagnosis: HLH ... genetic testing for HLH-associated ... If no response HLH ... TheIDtrivia #HLH
Open Fractures: Mechanisms, Clinical Features and Complications
Gustilo-Anderson Classification:
 • Type I
   - Wound <
Complications Gustilo-Anderson
Pancytopenia - Workup and Differential Diagnosis Algorithm
Consumption Disorders
 1. Autoimmune Mediated Pancytopenia
 2. Splenic Sequestration
Peripheral Destruction
and Screen for HLH ... HLH syndrome 5.