21 results
Hypokalemia Differential Algorithm
Acidosis
 - RTA
 - Diarrhea
pH Normal 
 1. Decreased Mg 
 2. Intracellular Shift
Hypokalemia Differential ... Metabolic alkalosis ... Algorithm #Diagnosis ... #Causes #Workup ... #Nephrology
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
thiazide-sensitive sodium-chloride ... H+ secretion → Hypokalemia ... Metabolic alkalosis ... Pathophysiology #nephrology ... #diagnosis
Causes of Hyponatremia - Differential Diagnosis Algorithm
Hypovolemia, UNa > 20: 
 • Renal losses, Diuretic excess,
Diagnosis Algorithm ... Hypovolemia, UNa ... tubal acidosis and metabolic ... alkalosis, Ketonuria ... #Causes #nephrology
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
Metabolic Alkalosis ... #Metabolic #Alkalosis ... urine #Algorithm #nephrology ... #differential # ... diagnosis
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
thiazide-sensitive sodium ... thiazide-sensitive sodium ... alkalosis • Normal ... ratio 0.5%) Differential ... #diagnosis #nephrology
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
Pressure: - Metabolic ... Alkalosis: Emesis ... #diagnosis #Algorithm ... #differential # ... potassium #nephrology
Causes of Seizures - Differential Diagnosis Algorithm
Unprovoked - Epilepsy:
 • Focal: Simple, Complex
 • Generalized: Absence,
: • Vascular: Stroke ... vasoconstriction syndrome ... Neurocysticercosis, PML • Metabolic ... Hypomagnesemia, Hypocalcemia ... #Causes #neurology
Causes of Hypokalemia
Transcellular Shifts:
 - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
Transcellular Shifts: - Alkalosis ... Heavy exercise, Heat ... stroke, Fever ... #Causes #differential ... #diagnosis #nephrology
Workup for Hypophosphatemia - Differential Diagnosis Framework
Rule out spurious hypophosphatemia: paraproteinemia, acute leukemia
Measure Urine Fractional Excretion
- Differential ... Diagnosis Framework ... Glucose, Acute resp. alkalosis ... , CA Inh., Osmotic ... #nephrology
Acid Base Disorders - Blood Gas Interpretation

Steps for Blood Gas Interpretation: 
1. Acidemia or Alkalemia? 
2.
Diagnosis: Causes ... D-lactate (short bowel syndrome ... sedation, narcotics, CVA ... Interpretation #Diagnosis ... #Summary #Nephrology