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diagnosis differential hematology neurology oncology vasculitis algorithm autoimmune chronic cll cord cvid hodgkins hypogammaglobulinemia immunodeficiency immunology infectiousdiseases leukemia lung lupus
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Immunodeficiency disorder ... Gastrointestinal inflammatory ... autoimmune hemolytic anemia ... ) • Systemic granulomatous ... , HIV) • Glucocorticoid
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
photosensitivity, inflammatory ... Classification: ... fibromyalgia) • Infections ... Induced Lupus: • Symptoms ... common • Antihistone
Multiple Sclerosis - Summary Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
Examination: • UMN signs ... Clonus, Babinski’s sign ... • Lhermitte’s sign ... pupillary defect SIGNS ... Signs and symptoms
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Symptoms (Sx) in ... , particularly scleritis ... purpura: strong sign ... Cryoglobulins • HIV ... #classification
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
and signs below ... Infections: - ... HIV, CMV, HTLV ... Inflammatory: ... , Sjogren syndrome
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
, particularly scleritis ... purpura: Strong sign ... Nodosa: • PAN most commonly ... ischemia • Skin: Erythematous ... : Ocular inflammatory
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Epidemiology: • Most common ... with no early symptoms ... weeks without infection ... Physical Exam/Signs ... • Neutropenia, anemia
Lung Infections in HIV - Differential Diagnosis Framework Disease by CD4 Count: Any CD4 Count: • Mycobacterium tuberculosis,
• CT: Halo sign ... papules, pustules, erythematous ... Constitutional symptoms ... 100% of cases), anemia ... #HIV #AIDS #pulmonary
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
History of EBV infection ... • Autoimmune disorders ... ingestion • B symptoms ... (NSHL) - (most common ... #management
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Diagnosis Framework Inflammatory ... Tenderness → Consider infectious ... papules and Gottron sign ... ) • Shawl sign ... • Conduction system
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