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differential lupus sle vasculitis arteritis classification cvid fungal gca giantcell hematology hypogammaglobulinemia immunodeficiency immunology mycoses myopathy pulmonary temporal variable vasculitides
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
effusion, Restrictive lung ... ) Blood (75%): Anemia ... #erythematosus ... #signs #symptoms ... #diagnosis #rheumatology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
lung disease ... hemolytic anemia ... ) • Systemic granulomatous ... syndrome, HIV) ... #diagnosis #management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
fibromyalgia) • Infections ... PNS and CNS • Headache ... Kidney disease common ... with Lupus: • Chronic ... #Diagnosis #Rheumatology
Lung Infections in HIV - Differential Diagnosis Framework Disease by CD4 Count: Any CD4 Count: • Mycobacterium tuberculosis,
Lung Infections ... • CT: Halo sign ... #Infections #HIV ... #AIDS #pulmonary ... #infectiousdiseases
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Eosinophilia, asthma, chronic ... to exclude are infections ... Symptoms (Sx) in ... purpura: strong sign ... #rheumatology #
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
signs/sx of inflammation ... complaints- anemia ... GCA #Temporal #Signs ... #Symptoms #Diagnosis ... #Management
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis ... Tenderness → Consider infectious ... papules and Gottron sign ... ) • Shawl sign ... • Conduction system
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
purpura: Strong sign ... Nodosa: • PAN most commonly ... ischemia • Skin: Erythematous ... Eosinophilia, asthma, chronic ... #Rheumatology
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
droppings • Most common ... cough, chills, headache ... • Rheumatologic ... yeast • At risk: AIDS ... #Management #Infections
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