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hematology differential oncology acute amiodarone aplastic apml arteritis capillary clarksons differentiation disease gbs gca giantcell guillain hiv immune induced inflammatory
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... CMV) • Epstein-Barr ... Treatment: ... • Improve the symptoms ... #diagnosis #management
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
high WBC count cause ... Dehydration • Symptoms ... unless worrisome EKG ... #TLS #diagnosis ... #management #hematology
Guillain-Barré Syndrome (GBS) Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness Epidemiology: • Incidence: 1
Guillain-Barré Syndrome ... than one after symptom ... and cauda equina TREATMENT ... #Syndrome #diagnosis ... #management #neurology
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Syndromes - OnePager ... recent DAN) • EMG ... or serologies + symptoms ... Goodpasture's cause ... #management #treatment
Acute Retroviral Syndrome Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection •
loss (>5 lb; 2.5 kg ... enzymes ↑ • Mild anemia ... DDX: • Epstein-Barr ... antibody test) Treatment ... #HIV #diagnosis
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Prednisone 5mg/kg ... Imaging: CXR- pulmonary ... : >3 symptoms, or ... #management #hematology
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
systemic complaints- anemia ... of the steroid treatment ... Treatment of GCA ... them, but urgent rheumatology ... #Diagnosis #Management
Clarkson’s Disease - Capillary leak syndrome Epidemiology: Roughly 150 published cases, Median age 50 years, No sex
Capillary leak syndrome ... filling +++ (risk of pulmonary ... ) • IVIg 2 g/kg ... #diagnosis #management ... #rheumatology
Amiodarone Induced Lung Toxicity Summary Who? • 5% of patients • Dose ≥ 400 mg per day How? Possible
starting amiodarone treatment ... respiratory distress syndrome ... gradually with symptoms ... Exclude other causes ... #diagnosis #management
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
Reconstitution Inflammatory Syndrome ... Lymphadenitis, pulmonary ... albicans • Epstein Barr ... #Inflammatory #Syndrome ... #Management
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