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hematology oncology amiodarone aplastic apml differentiation lung toxicity toxicology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... CMV) • Epstein-Barr ... Treatment: ... • Improve the symptoms ... #diagnosis #management
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
endothelial damage • Induce ... Prednisone 5mg/kg ... Imaging: CXR- pulmonary ... : >3 symptoms, or ... #management #hematology
Amiodarone Induced Lung Toxicity Summary Who? • 5% of patients • Dose ≥ 400 mg per day How? Possible
starting amiodarone treatment ... respiratory distress syndrome ... gradually with symptoms ... Improvement in symptoms ... #diagnosis #management
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