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hematology differential oncology amiodarone anemia aplastic capillary clarksons differentiation disease essential et gbs guillain immune induced inflammatory iris leak leukostasis
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Prednisone 5mg/kg ... Imaging: CXR- pulmonary ... : >3 symptoms, or ... #APML #diagnosis ... #management #hematology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
high WBC count cause ... Dehydration • Symptoms ... unless worrisome EKG ... #TLS #diagnosis ... #management #hematology
Guillain-Barré Syndrome (GBS) Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness Epidemiology: • Incidence: 1
Guillain-Barré Syndrome ... than one after symptom ... and cauda equina TREATMENT ... #Syndrome #diagnosis ... #management #neurology
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Syndromes - OnePager ... recent DAN) • EMG ... or serologies + symptoms ... Goodpasture's cause ... #management #treatment
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... CMV) • Epstein-Barr ... aplastic anemia Treatment ... • Improve the symptoms ... #diagnosis #management
Clarkson’s Disease - Capillary leak syndrome Epidemiology: Roughly 150 published cases, Median age 50 years, No sex
Capillary leak syndrome ... filling +++ (risk of pulmonary ... ) • IVIg 2 g/kg ... #diagnosis #management ... #rheumatology
Amiodarone Induced Lung Toxicity Summary Who? • 5% of patients • Dose ≥ 400 mg per day How? Possible
starting amiodarone treatment ... respiratory distress syndrome ... gradually with symptoms ... Improvement in symptoms ... #diagnosis #management
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
Reconstitution Inflammatory Syndrome ... leukoencephalopathy (PML ... albicans • Epstein Barr ... #Inflammatory #Syndrome ... #Management
Essential Thrombocythemia (ET) ET is a chronic myeloproliferative neoplasm. Most cases are related to mutations that affect
Most cases are related ... When present, symptoms ... • "Vasomotor" symptoms ... transformation into MDS or AML ... #diagnosis #management
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