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diagnosis algorithm lfts causes management obstetrics pathophysiology pregnancy transaminitis aplastic ascites biliary chemistry cholangitis cirrhosis comparison disease elevated enzymes gap
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... infiltration) Differential ... Diagnosis: Viral Hepatitis ... #Fatty #Liver # ... Pregnancy #hepatology
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
• Histology: Normal-mild ... (AFLP) • Onset ... Disease #Pregnancy #hepatology ... #obstetrics #hepatitis ... #comparison #differential
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... Wilsons, Pregnancy - AFLP ... NAFLD, Others • Mild ... Algorithm #diagnosis #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... • Pregnancy - AFLP ... • Alcoholic hepatitis ... Others #LFTs #Hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Check Acute viral hepatitis ... Check Acute viral hepatitis ... Chronic viral hepatitis ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... function may be abnormal ... #injury #hepatitis ... #differential # ... diagnosis #algorithm #hepatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
: - Hepatitis ... syndrome (MDS) (normal ... Marrow hypoplasia/fatty ... • Allogeneic HSCT ... #oncology #hematology
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
Abnormal liver function ... ALP, alkaline phosphatase ... non-alcoholic fatty ... #Algorithm #Hepatology ... #Differential #
Causes of Ascites Normal Peritoneum Portal hypertension (SAAG > 1.1 g/dL) 1. Hepatic congestionl
Causes of Ascites Normal ... - Alcoholic hepatitis ... - Acute fatty ... Causes #diagnosis #differential ... #hepatology #SAAG
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
obstruction • ALP ... or higher • Liver ... bile ducts Differential ... Diagnosis: • Viral hepatitis ... diagnosis #workup #hepatology
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