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diagnosis oncology algorithm anemia reactions workup aflp aplastic aspergillus betadglucan biomarkers bloodproduct boop calculation classification comparison components contents cop cryptogenic
Blood Product Components, Contents, Volume and Shelf Life Whole blood (autologous or directed donations) - RBC and
Blood Product Components ... Hct 35%. 450mL blood ... red cells have a Hct ... Hct 60% Platelet ... Contents #Volume #Hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
= (Retic %) x (Hct ... the peripheral blood ... infiltration (e.g. cancer ... Production #Index #hematology ... #anemia #differential
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
acid metabolism products ... AP, ↑INR, ↑BUN/Cr ... ↓Antithrombin Ill ... infiltration) Differential ... Liver #Pregnancy #hepatology
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
infection (IFI) in hematologic ... products - ... and allogeneic HSCT ... BAL GM does not differentiate ... 100d following HSCT
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Polycythemia - Differential ... Hb>16.5 g/dL, Hct ... Hb>16.0 g/dL, Hct ... Better call hematology ... Algorithm #workup #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Phagocytosis of blood ... cytokines (TNFa,lL1, IL6 ... B-LNH), solid cancers ... PTLD), allogeneic HSCT ... Lymphohistiocytosis #diagnosis #management
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Blood Product Transfusions ... May have drop in Hct ... Blood products contain ... #diagnosis #management ... #hematology #reactions
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
Fibrin degradation products ... decrease in most cases ... of Peripheral blood ... WBC count and differential ... Diagnosis #Workup #Hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
May have drop in Hct ... Causes purpura & ... Blood products contain ... #diagnosis #management ... #hematology #reactions
Cryptogenic Organizing Pneumonia (COP) Cryptogenic Organizing Pneumonia Overview: • Idiopathic form of organizing pneumonia • formerly BOOP
- Imaging: • CXR ... , cavities • HRCT ... • Pneumonia: blood ... BOOP #pulmonary #ILD ... #diagnosis #management
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