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diagnosis galactomannan aspergillus biomarkers causes comparison cutaneous dermatology emergencies eschar falsepositives hemeonc hospitalization laboratory mucormycosis oncologic oncology pathophysiology photo pseudoanemia
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
infection (IFI) in hematologic ... cut-offs defined in clinical ... and allogeneic HSCT ... 100d following HSCT ... #Biomarkers #BetaDGlucan
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives 1,3-Beta-D-Glucan • Cell wall component of many fungi
>90% (In most clinical ... in BAL does not differentiate ... False positives: Pip ... 100d following HCT ... blood products #BetaDGlucan
Anemia of Hospitalization - Pathophysiology Why does the Hgb/Hct drop in the first two days during hospitalization? Interestingly,
Why does the Hgb/Hct ... -6% drop in Hg/Hct ... 30 min and Hg/Hct ... concentrating Hg/Hct ... Decrease of Hg/Hct
Cutaneous Mucormycosis Eschar 30 M HIV cd4 10 VL 30k traumatic injury of arm few months ago
arm few months ago ... DM, hem CA, HSCT ... trauma, aplastic anemia ... systemic anti fungal ... #skin #clinical
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
suspected) - CT chest ... > 4 days → add fungal ... syndrome): - Hematologic ... - Occurs after CAR-T ... bispecifics, or HSCT
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