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management classification hematology algorithm antibodies bee erythematosus igg4 lupus monoclonal myopathy myositis neurology oncology paraproteinemias patterns phenotypes platelets prs pulmonary
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear Visual or auditory symptoms in conjunction
BEE Syndromes - ... less common diseases ... and treatment can ... Vogt-Koyanagi-Harada (VKH) disease ... disease • Multiple
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
Churg-Strauss syndrome ... purpura-arthralgia-nephritis syndrome ... - Goodpasture syndrome ... - Schnitzler syndrome ... - Sjögren syndrome
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Positive ANA ≠ Autoimmune ... SLE), Sjogren's Syndrome ... Arthritis, Sjögren Syndrome ... #patterns #rheumatology ... #diagnosis #differential
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Behçet's Syndrome ... Systemic disease ... syndrome (Clinical ... disease) Differential ... #Syndrome #diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Mucocutaneous lymph node syndrome ... : • Behçet Syndrome ... • Cogan Syndrome ... Diagnosis: Systemic ... differential #diagnosis
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
IgG4-Related Disease ... unique or multiple inflammatory ... female, asian • Systemic ... IgG4 #Related #Disease ... #treatment #rheumatology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
for workup, including ... , Vasculitides, ... IBD, Celiac disease ... Kawasaki, Nephrotic syndrome ... • Infections: Chronic
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
dermatomyositis, Sjogren syndrome ... rheumatologic diseases ... lymphoma • Evans' syndrome ... lymphoproliferative syndrome ... Shrinking lung syndrome
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Differential Diagnosis ... Mucocutaneous lymph node syndrome ... • Behcet syndrome ... • Cogan syndrome ... #Differential #Diagnosis
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... multisystemic disease ... SLE • Mikulicz syndrome ... enlargement Sjogren's Syndrome ... #Sjogrens #Syndrome
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