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classification differential ana antinuclear sle types vasculitis allergy associations comparison cryoglobulinemia cryoglobulins druginduced hypersensitivity laboratory pathophysiology reactions testing vasculitides
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
lupus erythematosus ... lupus erythematosus ... • Rheumatic Diseases ... • Non-Rheumatic ... #rheumatology #diagnosis
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Associated Rheumatic ... Diseases: • Homogeneous ... connective tissue disease ... lupus erythematosus ... #rheumatology #diagnosis
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
their Disease Associations ... hepatitis Anti-CCP, Rheumatoid ... (TTG) - Celiac disease ... #diagnosis #table ... antibodies
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... ANCA-associated vasculitis, rheumatoid ... Still disease, ... rheumatologic diseases ... #Diagnosis #Rheumatology
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
during hemolytic disease ... glomerulonephritis, rheumatoid ... arthritis, and ... systemic lupus erythematosus ... #Reactions #Table
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... Diseases • Septic ... lupus erythematosus ... #Disease #Rheumatoid ... #workup #diagnosis
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
diseases: - 10% ... respectively, having rheumatoid ... Elevated serum rheumatoid ... lupus erythematosus ... (SLE), rheumatoid
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
(Granulomatous disease ... : Systemic rheumatic ... diseases, such ... as systemic lupus ... atherosclerotic disease
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
- ANA > 95% (IgG ... Lupus Erythematosus ... Evolution: Chronic disease ... #rheumatology # ... diagnosis #management
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