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diagnosis sle vasculitis classification erythematosus ana antibodies antinuclear bee causes comparison cryoglobulinemia cryoglobulins disease druginduced hematology inflammatory laboratory management mimickers
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antibody refers ... Positive ANA ≠ Autoimmune ... context of other symptoms ... : Lupus (SLE), Systemic ... #patterns #rheumatology
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear Visual or auditory symptoms in conjunction
an underlying autoimmune ... • Systemic lupus ... spectrum disorder • ANCA-associated ... #neurology #inflammatory ... #differential #
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... Manifestations: - Arthritis ... #Diagnosis #autoantibodies ... #signs #symptoms ... #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... • Anti-Ro/SSA autoantibodies ... Diagnosis: • ANCA-associated ... rheumatologic diseases ... : • Symptoms limited
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
, Arthritis, myalgia ... months) and of autoantibodies ... months to years) Systemic ... Evolution: Chronic disease ... comparison #table #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Vasculitides - Differential ... inflammation Others: • Lupus ... lupus erythematosus ... Symptoms (Sx) in ... #diagnosis #rheumatology
Rhombencephalitis BACTERIAL - Listeria (biphasic illness with bulbar dysfunction occurring later) - Mycobacterium tuberculosis - Pneumococcus - Brucella - Borrelia (Lyme Disease) -
Toxoplasmosis AUTOIMMUNE ... - Systemic Lupus ... (bulbar symptoms ... anti-ganglioside antibody ... Diagnosis #Causes #Neurology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
diseases: - 10% ... DDX: • ANCA (Antineutrophil ... cytoplasmic antibody ... lupus erythematosus ... classification #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... Symptoms (SX) in ... affects the skin, neurologic ... • Progressive symptoms ... #Diagnosis #Rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... affected joint • Systemic ... lupus erythematosus ... ACE level, CXR, ANCA ... #laboratory #workup
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